Background: Phosphatidate phosphatases are a family of integral membrane glycoproteins that dephosphorylate a variety of lipid phosphates and play a role in signal transduction via the phospholipase D pathway. PAP-2 proteins function independently of Mg2+ and are insensitive to NEM (N-ethylmaleimide) inhibition. The lipid phosphates degraded by this family include ceramide 1-phosphate (C1P), sphingosine 1-phosphate (S1P), phosphatidic acid (PA) and lysophosphatidic acid (LPA). LPPR3 (Lipid phosphate phosphatase-related protein type 3), also known as PRG2 (Plasticity-related gene 2 protein) or PHP2 (PAP-2-like protein 2), is a 718 amino acid multi-pass membrane protein that mediates lipid phosphate phosphatase activity by catalyzing the conversion of 1,2-diacylglycerol 3-phosphate to 1,2-diacyl-sn-glycerol and phosphate. There are four isoforms of LPPR3 that are produced as a result of alternative splicing events.
Description: Rabbit polyclonal to LPPR3
Immunogen: KLH conjugated synthetic peptide derived from LPPR3
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 76 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
