Background: Mitogen-activated protein kinase associated protein 1 (MAPKAP-1) is a protein that localizes in the nucleus and is involved in several different signal transduction pathways. MAPKAP-1 contains one stress-activated map kinase interacting 1 domain (Pfam), a 2nd peroximal domain, and an ER membrane domain (Psort2). MAPKAP-1 binds to and inhibits c-Jun N-terminal kinase (JNK), and may act as a scaffold molecule in the regulation of JNK signaling. Transcription of the MAPKAP-1 gene is activated any time the organism is wounded, and stress to the cell causes the MAPKAP-1 protein to be phosphorylated. Cells lacking this protein may display sterility, multiple stress sensitivity, and a cell-cycle delay.
Description: Rabbit polyclonal to MAPKAP1
Immunogen: KLH conjugated synthetic peptide derived from MAPKAP1
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 59 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
