Background: CYP2F1 (cytochrome P450 2F1) is a human-specific membrane-bound protein usually localized to the endoplasmic reticulum membrane. Cytochromes, which are incredibly polymorphic, generally catalyze redox reactions. CYP2F1 is a lung-specific cytochrome P450 (pigment at 450 nm) that is involved in metabolizing potentially carcinogenic pneumotoxins. Its polymorphic nature likely has an impact on the sensitivity of an individual to such toxins. Specifically within Clara cells, CYP2F1 converts Skatole (3-methylindole) to 3-methyleneindolenine, an electrophile that disrupts cell functions by forming dangerous protein adducts. Skatole has been used to supplement flavor in cigarettes. CYP2F2 is the murine homolog of human CYP2F1.
Description: Rabbit polyclonal to CYP2F1
Immunogen: KLH conjugated synthetic peptide derived from CYP2F1
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 55 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
