Background: FVT1 (follicular variant translocation protein 1), also known as KDSR (3-ketodihydrosphingosine reductase) or DHSR, is a 332 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum (ER) and belongs to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed with highest expression in placenta, kidney, lung, small intestine and stomach, FVT1 catalyzes the NADP-dependent reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS), a key reaction in sphingolipid metabolism. In humans, defects in the gene encoding FVT1 are associated with follicular lymphoma (also known as type II chronic lymphatic leukemia), a common, slow-growing cancer arising from B-cells. Mutations in the gene encoding the corresponding bovine ortholog are associated with spinal muscular atrophy, a general term for a number of disorders characterized by a loss of motor neurons in the brainstem and spinal cord.
Description: Rabbit polyclonal to FVT1
Immunogen: KLH conjugated synthetic peptide derived from FVT1
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 36 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
