Background: Cysteine-rich proteins (CRPs) participate in the organization of multiprotein complexes, both in the cytoplasm, where they participate in cytoskeletal remodeling, and in the nucleus, where they facilitate smooth muscle differentiation. CRP1 (cysteine and glycine-rich protein 1), also known as CRP, CSRP1 or CYRP, is abundant in the prostate and smooth muscle lineages. It contains two LIM zinc-binding domains and is localized in the nucleus. The LIM domains of CRP1 are critical for binding to the adhesion-plaque protein Zyxin. CRP1 also interacts with a-actinin to mediate muscle differentiation. These associations indicate that the main function of CRP1 may be structural.
Description: Rabbit polyclonal to CSRP1
Immunogen: KLH conjugated synthetic peptide derived from CSRP1
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 21 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
