Background: MCC (mutated in colorectal cancers), also known as MCC1, is a coiled-coil protein that localizes to the cytoplasm. It is involved in cell cycle regulation, negatively regulating cell cycle progression during the G1 to S transition via a role in the NFκB signaling pathway. More specifically, MCC interacts with the NFκB inhibitor, IκBβ, playing a role in its stabilization and thereby inhibiting the nuclear translocation and signaling of NFκB. This suggests that MCC may act as a tumor suppressor. MCC is a phosphorylated protein and the state of phosphorylation changes in relation to the cell cycle. This implies that its function may be regulated by phosphorylation. MCC is highly phosphorylated during the transition from G1 to S phase and weakly phosphorylated in G0/G1. The overexpression of MCC results in a decreased number of cells entering S phase.
Description: Rabbit polyclonal to MCC
Immunogen: KLH conjugated synthetic peptide derived from MCC
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 93 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
