Background: Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. SorCS3 (sortilin-related VPS10 domain containing receptor 3) is a 1,222 amino acid single-pass type I membrane protein that contains one PKD domain and 6 BNR repeats. Highly expressed in brain, SorCS3 belongs to a subfamily of VPS proteins that are highly expressed in the nervous system where they function as neuronal receptors. The gene encoding SorCS3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie-Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Description: Rabbit polyclonal to SORCS3
Immunogen: KLH conjugated synthetic peptide derived from SORCS3
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 136 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
