Background: Members of the Antizyme (AZ) family are proteins that negatively regulate cellular polyamine synthesis and uptake. Three members, AZ1, AZ2 and AZ3, have been characterized to date. AZ1 and AZ2 have a broad tissue distribution, while AZ3 is expressed exclusively in testis. AZ2 (antizyme 2), also known as OAZ2 (ornithine decarboxylase antizyme 2) or ODC-Az 2, is a 189 amino acid protein that binds to ornithine decarboxylase (ODC), inactivates it, and targets it for degradation. The human and mouse AZ2 protein sequences differ by only one amino acid. One named isoform of AZ2 is produced by ribosomal frameshifting, which occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Description: Rabbit polyclonal to OAZ2
Immunogen: KLH conjugated synthetic peptide derived from OAZ2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 21 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
