Background: STOML3 [Stomatin (EPB72)-like 3], whose alternative names include Stomatin-like protein 3, Stomatin-related olfactory protein, SRO, SLP3, Epb7.2l, erythrocyte band 7 integral membrane protein or protein 7.2B, is a 291 amino acid single-pass type III membrane protein belonging to the band 7/mec-2 family. STOML3 is expressed in olfactory sensory neurons, with high expression in apical dendrites. STOML3 is also known to associate with A cyclase III and caveolin-1 in olfactory cilia. STOML3 is essential for regulating odorant signals in olfactory cilia lipid rafts and plays a role in mammalian mechanotransduction. Studies indicate that many ion channels of sensory neurons which depend on mechanical stimuli cannot function in the absence of STOML3. STOML3 contains two N-terminal hydrophobic domains and forms regions rich in beta sheets and alpha helices, which are common to members of the Stomatin family. The gene encoding STOML3 maps to human chromosome 13q13.3.
Description: Rabbit polyclonal to STOML3
Immunogen: KLH conjugated synthetic peptide derived from STOML3
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
