P53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53.
p53廣泛的研究發(fā)現(xiàn)P53腫瘤抑制基因?qū)?/SPAN>50%以上的人類癌癥具有抑制突變的功能。P53蛋白水平在正常細(xì)胞中表達(dá)低，在DNA突變時(shí)或各種各樣細(xì)胞遇難信號(hào)時(shí)反應(yīng)增加。該基因突變或缺失是導(dǎo)致許多腫瘤發(fā)生的原因。P53同時(shí)也是細(xì)胞凋亡的調(diào)控因子。此抗體可用于P53腫瘤抑制基因功能的研究。
我公司新研發(fā)的P53(p53細(xì)胞腫瘤抗原)抗體以及配對(duì)磷酸化p53 (phospho S371)抗體已經(jīng)通過(guò)檢驗(yàn)測(cè)試已經(jīng)通過(guò)檢驗(yàn)測(cè)試，可以應(yīng)用于蛋白印跡（WB），免疫組化（IHC），免疫細(xì)胞化學(xué)（ICC），酶聯(lián)免疫吸附試驗(yàn)（ELISA），免疫沉淀（IP），免疫熒光（IF）實(shí)驗(yàn)。具體信息如下：
編號(hào) 產(chǎn)品名稱
PR-1005， P53 Antibody
PR-1005P， p53 (phospho S371) Antibody
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鎮(zhèn)江厚普生物科技有限公司銷售部
2015-10-28